Stars Who Opened Up About Using GLP-1s: Changing the Conversation on Weight Loss

In the last few years, GLP-1 medications like Ozempic, Wegovy, and Mounjaro have dramatically shifted the landscape of weight loss in medicine, mainstream culture, and perhaps nowhere more visibly than among celebrities. Once designed to treat diabetes and obesity, these drugs are now household names, partly thanks to the openness of prominent figures discussing their journey with GLP-1s. For decades, celebrity transformations were shrouded in secrecy or speculation. Today, stars are shattering the stigma by sharing their stories, inspiring conversations about health, honesty, and the complexities of body image in the spotlight.

This article delves into the celebrities who have openly discussed their use of GLP-1s, what motivated them, the reactions from fans and critics, and what their honesty means for everyone navigating wellness in the era of medical innovation.

Understanding GLP-1s: The Science Behind the Hype

GLP-1 agonists are a class of medications originally developed for type 2 diabetes. These drugs work by mimicking a hormone that helps regulate appetite and blood sugar, often resulting in significant weight loss and reduced hunger. As the popularity of GLP-1s soared, so did demand—fuelled in no small part by celebrity endorsements and candid testimonials. Medications like Ozempic and Wegovy quickly found a second life beyond diabetes management, rebranding as tools for weight management or even “body transformation.”

Headline-Grabbing Celebrities Who Spoke Out

Oprah Winfrey: From Private Struggle to Public Conversation

After a lifetime in the public eye, where her weight was a persistent topic of media speculation and personal anguish, Oprah Winfrey announced she was using GLP-1s to help manage her weight. In interviews, she described her sense of relief, redemption, and her hope to end the stigma attached to medical weight management:

“The fact that there’s a medically approved prescription for managing weight…feels like relief, like redemption, like a gift, and not something to hide behind and once again be ridiculed for”.
Oprah’s openness sparked widespread discussion about obesity, self-blame, and how willpower is just one part of the story.

Elon Musk: Social Media and Full Disclosure

Billionaire entrepreneur Elon Musk made waves when he credited his 30-pound weight loss to a combination of fasting and GLP-1 medications (specifically, Ozempic/Wegovy). Via social media, Musk wrote:
“Fasting + Ozempic/Wegovy + no tasty food near me…”.

The simplicity of his statement cut through the noise, normalising the idea that even high-achieving figures need support in their health journeys.

Amy Schumer: Advocating for Authenticity

Comedian Amy Schumer has championed body positivity for years but hasn’t shied away from sharing her weight-loss journey, including her decision to use GLP-1s after the birth of her child. She’s been vocal in urging other celebrities to “be real” about their transformations rather than pretend they’re simply powered by willpower or crash diets.

Remi Bader: Candid About Challenges

Plus-size model and influencer Remi Bader has spoken openly about her initial success with GLP-1 medication due to pre-diabetes and insulin resistance. She noted significant appetite reduction, but also shared how she regained weight after discontinuing the injection underlining that these are not miracle cures and that side effects can include dependency or rebound weight gain.

Tracy Morgan and Charles Barkley: No Nonsense, Big Results

Comedian Tracy Morgan and basketball legend Charles Barkley have each credited their major weight losses to GLP-1 therapies. Morgan’s frank, humorous take “I take semaglutide every Thursday. Cuts my appetite in half” has helped demystify the process, while Barkley’s journey with Mounjaro (a GLP-1/GIP agonist) saw him lose over 60 pounds.

Sharon Osbourne: Success and Honest Side Effects

Osbourne, famed media personality, detailed her 42-pound weight loss using GLP-1s, but also acknowledged the downsides, including experiencing excessive weight loss and nausea. In her words,
“It’s not a dirty little secret when you’ve taken something to help you lose weight, which is perfectly fine”.

Reality TV and Social Media Stars: Bringing the Talk to New Audiences Members of the “Real Housewives” franchises, such as Emily Simpson, Margaret Josephs, Dolores Catania, and Lauren Manzo, have publicly shared their experiences with GLP-1 medications, often using these injections as a jump-start before focusing on diet and lifestyle. Their honesty has de-stigmatised medical assistance for weight loss among a massive TV and social media following.

Golnesa “GG” Gharachedaghi (Shahs of Sunset) used GLP-1 injectables and shared her step-by-step journey online not to endorse extreme weight loss, but to demystify the process and encourage transparency.

Whoopi Goldberg and Chelsea Handler: Breaking Taboos TV legends Whoopi Goldberg and Chelsea Handler have spoken about their use of Ozempic or Mounjaro on talk shows and podcasts. Handler described initially not realising she was prescribed Ozempic as part of a broader wellness routine, highlighting how the line between medical support and lifestyle can blur.

Key Themes and Insights From Celebrity Narrative

Destigmatising Medical Weight Loss

Celebrities being forthright about using GLP-1s are driving changes in public perception, reducing shame, and reframing obesity as a health condition instead of a character flaw. Many explicitly call for empathy and understanding, linking their experience to broader mental and physiological factors.

Setting Realistic Expectations

Celebrity testimonials regularly note that GLP-1s are not magic solutions. Most endorse pairing medication with healthy eating, exercise, and, perhaps most importantly, ongoing self-compassion. Many have also admitted to side effects, the necessity of lifestyle changes, and the risk of regaining weight after stopping the medication.

The Social Media Multiplier

Influencers and TikTok personalities have amplified the conversation, creating virtual support networks and opening up nuanced discussions—ranging from initial excitement to concerns about cost, accessibility, and potential side effects.

The Broader Impact: From Hollywood to the General Public

The openness of stars has made GLP-1 medications a frequent topic in both medical and pop culture, helping many feel validated for seeking prescription aid. However, their influence is double-edged: while they help destigmatise these drugs for medical obesity, there are worries about overuse, shortcuts, or pressure to meet unrealistic appearance standards.

Conclusion

As stars continue to break the silence around their use of GLP-1 medications, they are helping millions reframe not just how they view quick-fix transformations but also how they talk about health, willpower, and medical innovation. Their stories anchor hope, empathy, and transparency reminding us that seeking help, celebrating progress, and being honest about setbacks are all part of the journey to better health.

Whether you’re inspired by Oprah’s candour, Elon Musk’s pragmatism, Amy Schumer’s authenticity, or the reality TV crowd’s honesty, the takeaway is clear: it’s time to move past stigma and embrace a diverse, science-backed view of weight management for everyone.

This article reflects celebrity disclosures and wellness trends as of July 2025, drawing on both mainstream news and first-hand accounts from public figures.